Tanmay A. M. Bharat is a research group leader at the MRC Laboratory of Molecular Biology. He and his group use physical structure and cell biology methods to study the surface of bacteria and the biofilms that they form. This is increasing understanding of how bacteria can resist antibiotics and act as pathogens. He has been awarded several prizes and fellowships for his work.[1][2]

Education

Bharat graduated with a BA in Biological Sciences from the University of Oxford, UK. His studies were supported by a Rhodes Scholarship. He then undertook research at the European Molecular Biology Laboratory in Heidelberg, Germany for his PhD working with John A. G. Briggs.[3] He studied the structure and assembly of pathogenic viruses using cryogenic electron microscopy and tomography. His work on several viral capsid proteins improved understanding of how viruses are assembled within infected cells.[4][5][6][7]

Research

He subsequently returning to the MRC Laboratory of Molecular Biology to pursue research using cryo-EM to study proteins within cells. initially as a post-doctoral fellow with Jan Löwe then leading his own research group.[3] His appointment was joint with the Sir William Dunn School of Pathology, University of Oxford. The research that he leads investigates how bacteria and archaea use their surface proteins to interact with the exterior environment, especially during infections and when part of a biofilm that bacteria use to evade antibiotics. The group also use electron tomography.[4]

Scientific publications

Bharat is the author or co-author of over 43 scientific publications. These include.

Awards

Bharat has been awarded many prizes and fellowships.[3] These include a Vallee Scholar Award in 2018,[3] Lister Research Prize Fellowship in 2021,[8] the Colworth Medal by the Biochemical Society[4] in 2022 and the Fleming Prize Lecture by the Microbiology Society in 2023 for structural studies of prokaryotic cell surfaces.[2]

References

  1. ↑ "Tanmay Bharat Prokaryotic cell surfaces". MRC Laboratory of Molecular Biology. UKRI. Retrieved 26 October 2023.
  2. 1 2 "FLEMING PRIZE WINNERS". Microbiology Society. Retrieved 28 April 2020.
  3. 1 2 3 4 "Vallee Scholar Awards: Tanmay Bharat, PhD". The Vallee Foundation. Retrieved 26 October 2023.
  4. 1 2 3 "The Colworth Medal". Biochemical Society. Retrieved 8 September 2022.
  5. ↑ Bharat, Tanmay A. M.; Riches, James D.; Kolesnikova, Larissa; Welsch, Sonja; Krähling, Verena; Davey, Norman; Parsy, Marie-Laure; Becker, Stephan; Briggs, John A. G. (2011-11-15). "Cryo-electron tomography of Marburg virus particles and their morphogenesis within infected cells". PLOS Biology. 9 (11): e1001196. doi:10.1371/journal.pbio.1001196. ISSN 1545-7885. PMC 3217011. PMID 22110401.
  6. ↑ Bharat, Tanmay A. M.; Noda, Takeshi; Riches, James D.; Kraehling, Verena; Kolesnikova, Larissa; Becker, Stephan; Kawaoka, Yoshihiro; Briggs, John A. G. (2012-03-13). "Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography". Proceedings of the National Academy of Sciences of the United States of America. 109 (11): 4275–4280. Bibcode:2012PNAS..109.4275B. doi:10.1073/pnas.1120453109. ISSN 1091-6490. PMC 3306676. PMID 22371572.
  7. ↑ Bharat, Tanmay A. M.; Davey, Norman E.; Ulbrich, Pavel; Riches, James D.; de Marco, Alex; Rumlova, Michaela; Sachse, Carsten; Ruml, Tomas; Briggs, John A. G. (2012-07-19). "Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy". Nature. 487 (7407): 385–389. Bibcode:2012Natur.487..385B. doi:10.1038/nature11169. ISSN 1476-4687. PMID 22722831. S2CID 4423300.
  8. ↑ "Tanmay Bharat Awarded Lister Institute Research Prize". Sir William Dunn School of Pathology. Retrieved 26 October 2023.
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