TMEM165
Identifiers
AliasesTMEM165, CDG2K, FT27, GDT1, TMPT27, TPARL, transmembrane protein 165, SLC64A1
External IDsOMIM: 614726 MGI: 894407 HomoloGene: 5411 GeneCards: TMEM165
Orthologs
SpeciesHumanMouse
Entrez

55858

21982

Ensembl

ENSG00000134851

ENSMUSG00000029234

UniProt

Q9HC07

P52875

RefSeq (mRNA)

NM_018475

NM_011626

RefSeq (protein)

NP_060945

NP_035756

Location (UCSC)Chr 4: 55.4 – 55.45 MbChr 5: 76.33 – 76.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane protein 165 is a protein that in humans is encoded by the TMEM165 gene.[5]

Model organisms

Model organisms have been used in the study of TMEM165 function. A conditional knockout mouse line, called Tmem165tm1e(EUCOMM)Wtsi[11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][15] Twenty three tests were carried out on mutant mice and two significant abnormalities were observed.[9] Homozygous mutant males had skeletal deformities, including scoliosis, and an increased susceptibility to bacterial infection.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134851 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029234 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Transmembrane protein 165". Retrieved 2011-12-06.
  6. ↑ "Radiography data for Tmem165". Wellcome Trust Sanger Institute.
  7. ↑ "Salmonella infection data for Tmem165". Wellcome Trust Sanger Institute.
  8. ↑ "Citrobacter infection data for Tmem165". Wellcome Trust Sanger Institute.
  9. 1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ↑ "International Knockout Mouse Consortium".
  12. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  15. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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