Ryszard Kole
Education
Awards
Scientific career
Fields
InstitutionsUniversity of North Carolina at Chapel Hill

Ryszard Kole (Polish: [ˈrɨʂard ˈkɔlɛ]) is a Polish-American pharmacologist and professor emeritus in the Pharmacology Department at the UNC School of Medicine within the University of North Carolina at Chapel Hill. He is known for his research on control of gene expression by antisense oligonucleotides and messenger RNA-based therapeutics.[1] He is the recipient of the 2019 Massry Prize.

Life and career

He graduated in chemistry from the University of Warsaw in 1969. Between 1970–1977, he held the position of senior research associate at the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences (PAN), where he obtained his PhD degree. His research there mostly concerned the role of ribonucleases on cell function.[2]

In 1977, he moved to the United States where, as a postdoctoral fellow, he trained with Sidney Altman and Sherman Wiseman at Yale University. In 1983, joined the faculty of the University of North Carolina at Chapel Hill as Professor of Pharmacology.[3] His studies focus on a cellular process called mRNA splicing, which modulates the flow of genetic information in all human cells from the DNA inside nuclei to the generation of mRNA in the cytoplasm, followed by production of functional proteins.[4]

He is a member of the American Society of Gene and Cell Therapy and Oligonucleotide Therapeutics Society (OTS). He authored more than 100 scientific publications, trained more than 40 graduate students and postdoctoral researchers, and is a co-inventor on more than 30 national and international patents.[5]

He served as the senior vice president of discovery for AVI BioPharma, and is a former executive for Sarepta Therapeutics.

In 2019, he became the joint recipient of the Massry Prize, alongsdie Stanley T. Crooke, for "their seminal work in the development of oligonucleotides targeting messenger RNA as novel therapeutics for a wide range human diseases".[6]

See also

References

  1. ↑ "Ryszard Kole, PhD". med.unc.edu. Retrieved 5 November 2023.
  2. ↑ "Biographical sketch" (PDF). med.unc.edu. Retrieved 5 November 2023.
  3. ↑ "2020 OTS Lifetime Achievement Award Winner Ryszard Kole, PhD". oligotherapeutics.org. 16 September 2020. Retrieved 5 November 2023.
  4. ↑ "Kole Wins Massry Prize". news.unchealthcare.org. 29 October 2019. Retrieved 5 November 2023.
  5. ↑ "Kole Wins Massry Prize". news.unchealthcare.org. 29 October 2019. Retrieved 5 November 2023.
  6. ↑ "Massry Prize 2019 | Keck School of Medicine of USC". 15 October 2019. Retrieved 5 November 2023.
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