POLR3G

POLR3G
Identifiers
Aliases	POLR3G, RPC32, RPC7, polymerase (RNA) III subunit G, RNA polymerase III subunit G, C31
External IDs	OMIM: 617456 MGI: 1914736 HomoloGene: 38184 GeneCards: POLR3G
Gene location (Human)
Chr.	Chromosome 5 (human)
End	90,514,557 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	81,859,132 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; sural nerve; ; secondary oocyte; ; internal globus pallidus; ; monocyte; ; trigeminal ganglion; ; cerebellar hemisphere; ; substantia nigra; ; pancreatic ductal cell; ; stromal cell of endometrium;
	Top expressed in
	morula; ; primitive streak; ; esophagus; ; facial motor nucleus; ; yolk sac; ; urothelium; ; epidermis; ; lip; ; hair follicle; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; protein binding;
Cellular component	RNA polymerase III complex; cytosol; nucleoplasm; nucleus; cytoplasm;
Biological process	positive regulation of interferon-beta production; immune system process; cell population proliferation; defense response to virus; positive regulation of innate immune response; innate immune response; regulation of transcription by RNA polymerase III; transcription by RNA polymerase III; positive regulation of type I interferon production;
	Sources:Amigo / QuickGO
Orthologs
	10622
	67486
	ENSG00000113356
	ENSMUSG00000035834
	O15318
	Q6NXY9
	NM_006467; NM_001370351; NM_001370352; NM_001370353; NM_001370354
	NM_001081176; NM_026190
	NP_006458; NP_001357280; NP_001357281; NP_001357282; NP_001357283
	NP_001074645
	Wikidata
View/Edit Human	View/Edit Mouse

Polymerase (RNA) III (DNA directed) polypeptide G (32kD) is a protein that in humans is encoded by the POLR3G gene. ^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113356 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035834 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Polymerase (RNA) III (DNA directed) polypeptide G (32kD)". Retrieved 2014-04-01.

Ablasser, A; Bauernfeind, F; Hartmann, G; Latz, E; Fitzgerald, K. A.; Hornung, V (2009). "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate" (PDF). Nature Immunology. 10 (10): 1065–72. doi:10.1038/ni.1779. PMC 3878616. PMID 19609254.
Chiu, Y. H.; MacMillan, J. B.; Chen, Z. J. (2009). "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway". Cell. 138 (3): 576–91. doi:10.1016/j.cell.2009.06.015. PMC 2747301. PMID 19631370.
Chantarangsu, S; Mushiroda, T; Mahasirimongkol, S; Kiertiburanakul, S; Sungkanuparph, S; Manosuthi, W; Tantisiriwat, W; Charoenyingwattana, A; Sura, T; Takahashi, A; Kubo, M; Kamatani, N; Chantratita, W; Nakamura, Y (2011). "Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash". Clinical Infectious Diseases. 53 (4): 341–8. doi:10.1093/cid/cir403. PMID 21810746.
Wong, R. C.; Pollan, S; Fong, H; Ibrahim, A; Smith, E. L.; Ho, M; Laslett, A. L.; Donovan, P. J. (2011). "A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells". Stem Cells. 29 (10): 1517–27. doi:10.1002/stem.714. PMID 21898682. S2CID 24305950.
Jang, K. L.; Collins, M. K.; Latchman, D. S. (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–7. PMID 1403646.
Wang, Z; Roeder, R. G. (1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
Hu, P; Wu, S; Sun, Y; Yuan, C. C.; Kobayashi, R; Myers, M. P.; Hernandez, N (2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113356 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035834 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Polymerase (RNA) III (DNA directed) polypeptide G (32kD)". Retrieved 2014-04-01.

[1]

[2]

[3]

[4]

[5]

References

Further reading