Season 1

The show revolves around a Malayalee homemaker, Sumithra Menon and her family. Sumithra, a devoted housewife, mother and daughter-in-law, is family-oriented and self-sacrificing. Sumithra is married to Siddharth Menon and has three children; Anirudh Menon, a doctor, Pratheesh Menon, an aspiring musician, and Sheetal Menon, a college student. They live with Siddharth's parents, Shivadas and Saraswati. Except for Shivadas, Pratheesh, Sreekumar and their servant Mallika, no one cares for Sumitra's happiness or feelings. In addition to this misery, Siddharth divorces her and marries Vedhika. Initially devastated, she realises her worth and attempts to rediscover herself. How she transforms into a head-strong woman and gains the love of her family forms the crux of this soap-opera. She starts her business "Sumithra's" which makes her a business magnate. In these days, everyone except Saraswati realised Sumithra's importance. Later, Sidharth files divorce case against Vedhika in order to remarry Sumithra but Sumithra gets remarried with her old classmate and friend Rohit. Vedhika didn't want divorce and she argues in the court for not allowing separation. But some days after Vedhika became a cancer patient but Sidharth didn't took care of her and threw her out of the home. Sumithra takes her to Sreenilayam and they became good friends. Vedhika recovered from the disease. Later Sidharth met with an accident and got full body paralyzed. Sumithra and family looked him very well and he slowly recovered. Shivadas died due to heart failure during his ninetieth birthday. The incident shocked Sreenilayam family. After a few days, Pratheesh and Sanjana with their child moved to Chennai and Ananya moved to abroad where Anirudh is working, Vedhika got out of Sreenilayam and went to Sampath, her ex-husband to meet her son Neerav and request him to send Neerav to her mother's home where she lives for just three months before they shift to Abroad. Sampath didn't agreed but after several requests, he allowed her to stay at this house for 3 months. Then Vedhika and Sidharth got divorced. Sampath remarried Vedhika and lived peacefully with their child. Rohit and Sumithra moved to Rohit's house. Sidharth moved from Sreenilayam to find a job after writing a letter thus making Saraswati alone at the house. Saranya, her daughter take her mother to her husband's home but she began to advice Saranya to took over control to Sreekumar, Saranya's husband. This made Sreekumar angry and asked Saranya to move her out of thir home. Saranya took her to an old age home. Then Sumithra started a new life with Rohit and Pooja.

Season 2

Main

• Meera Vasudevan as Sumithra^[7] (formerly Menon) – Savithriyamma's daughter; Deepu's sister; Sidharth's ex-wife; Anirudh, Pratheesh and Sheethal's mother; Pooja's step-mother; Rohit's wife.
• Krishnakumar Menon as Sidharth "Sidhu" Menon^[8] – Shivdas and Saraswathiyamma's son; Sumithra and Vedhika's ex-husband; Anirudh, Pratheesh and Sheethal's father; Sharanya's brother.
• Shwetha Venkat^[9] / Ameya Nair^[10] / Saranya Anand^[11] as Vedika Menon – Vasumatiyamma's daughter; Sampath's wife, Siddharth's ex-wife; Neerav's mother.
• Dr. Shaju Shaam as Rohith Gopal^[12] – Sumithra's classmate and husband; Pooja's father;

Recurring

The Sreenilayam family

• F. J. Tharakan as Shivadas Menon^[13] – Saraswathi's husband; Sidharth and Sharanya's father; Anirudh, Pratheesh and Sheetal's grandfather; Sreekumar and Vedhika's father-in-law; Sumithra's ex-father-in-law.
• Devi Menon as Saraswathi Menon aka Saraswathiyamma^[14] – Shivdas's wife; Sidharth and Sharanya's mother; Anirudh, Pratheesh and Sheetal's grandmother; Sreekumar and Vedhika's mother-in-law; Sumithra's ex-mother-in-law.
• Sreejith Vijay^[15] / Anand Narayan^[16] as Dr. Anirudh Menon – Sumithra and Sidharth's elder son; Pratheesh and Sheetal's brother; Ananya's husband; Pooja's stepbrother ; Rohit's stepson.
• Akshaya R. Nair / Athira Madhav^[17] / Aswathy Ash^[18] as Dr. Ananya Menon – Prema's daughter; Anirudh's wife; Sumithra and Sidharth's daughter-in-law; Pratheesh,Pooja and Sheetal's sister-in-law.
• Noobin Johny as Pratheesh Menon^[19] – Sumithra and Sidharth's younger son; Anirudh and Sheetal's brother; Sanjana's husband; Pooja's stepbrother ; Rohit's stepson.
• Reshma Nandu as Sanjana Menon^[20] – Ramakrishnan's daughter; Susheela's stepdaughter; Maneesh's widow; Pratheesh's wife; Sumithra and Sidharth's daughter-in-law; Anirudh, Pooja and Sheetal's sister-in-law.
• Parvathi Vijay^[21] / Amritha Nair^[22] / Sreelakshmi Sreekumar^[23] as Sheetal Menon – Sumithra and Sidharth's daughter; Anirudh and Pratheesh's sister; Pooja's stepsister; Rohit's stepdaughter, Sachin's wife
• Manoj Nair^[24] / Sumesh Surendran as Sreekumar – Sharanya's husband; Nileena's former love interest
• Sindhu Varma / Manju Satheesh^[25] as Saranya Menon Sreekumar – Shivadas and Saraswathiyamma's daughter; Sidharth's sister; Sreemukar's wife; Anirudh, Pratheesh and Sheetal's aunt; Sumithra's ex-sister-in-law; Vedhika's sister-in-law.
• Manju Vijeesh as Mallika – Sreenilayam family's domestic help^[26]

Others

• Padmakumar as CI Narayanan Kutty – Circle Inspector of Police
• Gouri Prakash/ Aiswarya Unni as Pooja Gopal^[27] – Rohit's daughter; Sheetal's friend
• Bindhu Pankaj as Nileena Bhaskar – Sumithra's best friend since college; Shreekumar's former love interest
• Jithu Venugopal as Anoop,^[28] a goon who works for Mahendran
• Fawaz Zayani/ Naveen Arakkal as Sampath^[29] – Vedhika's ex-husband; Neerav's father
• Shahnu / Amrutha S Ganesh as Dr. Indraja - Anirudh's superior
• Hari as Deepankuran aka Deepu – Savithri's son; Sumithra's brother; Chithra's husband; Jishnu's father
• Sunitha as Savithri aka Savithriyamma – Sumithra and Deepu's mother; Anirudh, Pratheesh, Sheethal and Jishnu's grandmother; Rohit's mother-in-law; Sidharth's ex-mother-in-law.
• Parvathy Raveendran as Chitra – Deepu's wife; Jishnu's mother
• Krishna as Premajam – Ananya's mother
• Angeline Mariya - Maya
• Firosh Mohan as Naveen – Vedika's friend
• K. P. A. C. Saji / Amboori Jayan as Ramakrishnan – Sanjana's father
• Devi Chandana as Susheela - Ramakrishnan's second wife
• Hari as Vivek - Rohith's friend
• Akhil as Jishnu – Deepu and Chithra's son; Anirudh, Pratheesh and Sheethal's cousin
• Swathi Thara as DCP Chandralekha – IPS officer
• Renjusha Menon as SI Nirmala
• Sruthisha Nair as Shilpa – Member of Pratheesh's band who loves him
• Sreerang Shine as Neerav – Sampath and Vedika's son
• Geetha Nair as Vasumati aka Vasumatiyamma – Vedika's mother
• Shobi Thilakan as Adv. Vasudevan – Sumithra and Siddharth's divorce lawyer
• Sarath Sreehari as Pianist – Pratheesh's bandmate
• Divya Sreedhar as Preetha's mother
• Saju Kodiyan as Rev. Francis Mupliyanthadathil – Sheethal's school principal
• Vanchiyoor Praveen Kumar as Udayabhanu – Shivadas's colleague who works at a resort
• Jeevan Gopal as Jithin Raj – A fraudster and drug addict who wants to marry Sheetal^[30]
• Alif Muhammed as Maneesh – Sanjana's first husband (dead)
• Sheelasree as Maneesh's mother
• Joe Varghese as Sajin – Sheetal's boyfriend, later turned husband
• Maria Juliana as Deepa
• Sivaji Guruvayoor as Ananthan Vaidyar

Guest appearances

• Innocent as the chief guest at the Mother's Day Competition at Sheetal's school (episodes 5 and 6)
• Aju Varghese as himself, for the inauguration of Sumithra's shop (Episode 205)^[31]
• Neena Kurup as Kanaka ( episode 890)