CLUAP1
Identifiers
AliasesCLUAP1, CFAP22, FAP22, IFT38, clusterin associated protein 1
External IDsOMIM: 616787 MGI: 1924029 HomoloGene: 14831 GeneCards: CLUAP1
Orthologs
SpeciesHumanMouse
Entrez

23059

76779

Ensembl

ENSG00000103351

ENSMUSG00000014232

UniProt

Q96AJ1

Q8R3P7

RefSeq (mRNA)

NM_015041
NM_024793
NM_001330454

NM_029738

RefSeq (protein)

NP_001317383
NP_055856
NP_079069

NP_084014

Location (UCSC)Chr 16: 3.5 – 3.54 MbChr 16: 3.73 – 3.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clusterin associated protein 1, also known as CLUAP1, is a human gene.[5]

Model organisms

Model organisms have been used in the study of CLUAP1 function. A conditional knockout mouse line, called Cluap1tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty six tests were carried out on mutant mice and four significant abnormalities were observed.[9] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; both sexes had decreased IgG1 levels while males also displayed abnormal spine curvature resulting in kyphosis.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103351 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014232 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: clusterin associated protein 1". Retrieved 2011-08-30.
  6. ↑ "Radiography data for Cluap1". Wellcome Trust Sanger Institute.
  7. ↑ "Salmonella infection data for Cluap1". Wellcome Trust Sanger Institute.
  8. ↑ "Citrobacter infection data for Cluap1". Wellcome Trust Sanger Institute.
  9. 1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ↑ "International Knockout Mouse Consortium". Archived from the original on 2012-05-29. Retrieved 2012-02-14.
  12. ↑ "Mouse Genome Informatics".
  13. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. S2CID 39281705.
  15. ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.