![]() Bgee gene expression database logo | |
Content | |
---|---|
Description | Gene expression across species and conditions |
Data types captured | scRNA-Seq, RNA-Seq, Microarray, In situ and EST Data |
Organisms | Human, Mouse, Rat, Fruit-fly, Chicken, Roundworm, Wild boar, Zebrafish, Cow and others. |
Contact | |
Research center | Swiss Institute of Bioinformatics University of Lausanne |
Primary citation | PMID 33037820 |
Release date | June 2007 |
Access | |
Website | www |
Download URL | www |
Sparql endpoint | www |
Tools | |
Web | Gene search TopAnat: Gene Expression Enrichment Expression comparison Anatomical homology Annotation interface |
Standalone | bioconductor |
Miscellaneous | |
License | CC0 1.0 Universal |
Version | 15.1 |
Curation policy | Manual curation of every study. |
Bgee is a database maintained by the Swiss Institute of Bioinformatics and the University of Lausanne for retrieval and comparison of gene expression patterns from RNA-Seq, scRNA-Seq, Microarray, In situ hybridization and EST studies, across multiple animal species.[1][2] Bgee provides an intuitive answer to the question where is a gene expressed? and supports research in cancer and agriculture, as well as evolutionary biology.
Bgee is based exclusively on curated normal, healthy wild-type, expression data (e.g., no gene knock-out, no treatment, no disease), to provide a comparable reference of normal gene expression.
Bgee produces calls of presence/absence of expression, and of differential over-/under-expression, integrated along with information of gene orthology, and of homology between organs. This allows comparisons of expression patterns between species.
Bgee allows searches by gene, organs / tissue / cell type and developmental stage.
References
- ↑ Bastian FB, Parmentier G, Roux J, Moretti S, Laudet V, Robinson-Rechavi M (2008). "Bgee: Integrating and Comparing Heterogeneous Transcriptome Data Among Species". Lecture Notes in Computer Science. 5109: 124–131. doi:10.1007/978-3-540-69828-9_12.
- ↑ Bastian FB, Roux J, Niknejad A, Comte A, Fonseca Costa SS, Mendes de Farias T, et al. (Jan 2021). "The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals". Nucleic Acids Research. 49 (D1): D831–D847. doi:10.1093/nar/gkaa793. PMC 7778977. PMID 33037820.
Further reading
- Niknejad A, Mungall CJ, Osumi-Sutherland D, Robinson-Rechavi M, Bastian F (2022). "Creation and unification of development and life stage ontologies for animals". arXiv. doi:10.48550/arXiv.2206.12231.
- Komljenovic A, Roux J, Wollbrett J, Robinson-Rechavi M, Bastian F (2018). "BgeeDB, an R package for retrieval of curated expression datasets and for gene list expression localization enrichment tests". F1000Research. 5: 2748. doi:10.12688/f1000research.9973.2. PMC 6113886. PMID 30467516.
- Haendel MA, Balhoff JP, Bastian FB, Blackburn DC, Blake JA, Bradford Y, et al. (2014). "Unification of multi-species vertebrate anatomy ontologies for comparative biology in Uberon". J Biomed Semantics. 5: 21. doi:10.1186/2041-1480-5-21. PMC 4089931. PMID 25009735.
External links
- "About Bgee". SIB Swiss Institute of Bioinformatics.