Two-Spirit (also two spirit or twospirit) refers to Native Americans who fulfill one of many mixed gender roles found traditionally among many North American indigenous groups. Traditionally the roles included wearing the clothing and performing the work of both male and female genders. The term usually implies a masculine spirit and a feminine spirit living in the same body and was coined by contemporary LGBT Native Americans to describe themselves and the traditional roles they are reclaiming. There are many terms for these individuals in various indigenous languages. As of 1991, male and female bodied Two-Spirit people have been "documented in over 130 tribes, in every region of North American, among every type of native culture".

Jake Zyrus is a Filipino singer and television personality. Prior to his gender transition to male, he performed under the mononym Charice. In 2007, after some appearances on Philippine television, Zyrus sang on The Ellen DeGeneres Show, and the following year, he made several international television appearances, including on The Oprah Winfrey Show. He then began performing in concerts with David Foster and Andrea Bocelli, among others. Zyrus released the studio album Charice in 2010; it entered the Billboard 200 at number eight, making it the first album of an Asian solo singer ever to land in the Top 10. The single "Pyramid" from that album, featuring singer Iyaz, is Zyrus's most successful single to date, charting within the Top 40 in a number of countries after its debut live performance on The Oprah Winfrey Show. Crossing over to acting on television, he joined the cast of TV series Glee later in 2010 as Sunshine Corazon. In 2011, "Before It Explodes", written by Bruno Mars, was released as the lead single from Zyrus's second international studio album, Infinity.

Zyrus was one of the four judges of the Philippine version of The X Factor, on ABS-CBN, in 2012. He first came out as a lesbian in 2013. He released further albums Chapter 10 in 2013 and Catharsis in 2016. He began using his current name in 2017 after beginning hormone replacement therapy.

• ... that after trans woman Dylan Mulvaney was sponsored by Bud Light, American conservatives boycotted the brand and its parent company Anheuser-Busch?
• ... that The Hidden Case of Ewan Forbes discusses the history of transgender man Ewan Forbes and his 1968 legal case to inherit his family's baronetcy that was silenced from public records?
• ... that transgender pioneer Barbara Ann Wilcox proposed to her husband on the day she met him?
• ... that trans man Iszac Henig alternated wins against trans woman Lia Thomas on the way to the 2022 NCAA Division I Women's Swimming Championship?
• ... that when Sarah Jane Baker was released after 30 years, she was the United Kingdom's longest serving transgender prisoner?
• ... that Sarah Ashton-Cirillo, covering the Russian invasion of Ukraine, said that Ukrainians care less about her being transgender than Americans do?

Chelsea Manning

• 1 – Janelle Monae (1985), American non-binary singer, actress and author
• 4 – Mina Caputo (1973), American singer
• 12 – Brandon Teena (1972–1993), American trans man murder victim
• 17 – Chelsea Manning (1987), American activist and whistleblower
• 19 – King Princess (1998), American genderqueer singer-songwriter
• 20 – Bell Nuntita (1983), Thai actress, singer
• 22 – Sandra Forgues (1969), French canoeist, olympic medalist, transgender woman
• 25 – Mianne Bagger (1966), Danish golfer
• 28 – Lili Elbe (1882–1931), Danish transgender artist
• 28 – Lilly Wachowski (1967), American director, writer, producer
• 29 – Billy Tipton (1914–1989), American musician and bandleader
• 31 – Diana Sacayán (1975–2015), Argentinian transgender rights activist

Question mark

• ... that the 2015 State of the Union Address was the first State of the Union Address in which the President of the United States used the words "gay", "lesbian", and "transgender"?
• ... that Nicole Maines won a Maine Supreme Court ruling that denying transgender students access to the bathroom consistent with their gender was unlawful, and went on to become the superheroine Dreamer in the television series Supergirl?
• ... that in 1776, a person reported being genderless, changed names to the Public Universal Friend, dressed androgynously, asked not to be referred to with gendered pronouns, and has been called a chapter in transgender history "before 'transgender'"?

When I was perceived as a black man I became a threat to public safety. When I was dressed as myself, it was my safety that was threatened.