Ottoman-Spanish War may refer to:
- Crusade of Nicopolis part of the Crusades
- Ottoman–Venetian War (1463–1479)
- Ottoman conquest of Otranto
- Ottoman–Venetian War (1499–1503)
- Spanish-Ottoman Wars of 1515-1577
- Italian War of 1536–1538
- Italian War of 1542–1546
- Italian War of 1551–1559
- Ottoman–Portuguese conflicts (1586–1589)
- Long Turkish War
- Great Turkish War
- Ottoman–Venetian War (1714–1718)
- Egyptian–Ottoman War (1839–1841)
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