Hesychius (Ancient Greek: Ἡσύχιος, romanized: Hēsúkhios, lit. 'the quiet one') may refer to:

• Hesychius of Cazorla (first century), Spanish Christian missionary, bishop, martyr and saint
• Hesychius of Antioch (fourth century), Antioch saint
• Hesychius of Sinai (fourth century), Byzantine hieromonk and author
• Hesychius of Alexandria (probably fifth century), Alexandrian lexicographer
• Hesychius of Jerusalem (probably fifth century), Jerusalem Christian presbyter and exegete
• Hesychius I (bishop of Vienne) (fifth century), French bishop and saint
• Hesychius II (bishop of Vienne) (sixth century), French bishop and saint
• Hesychius I (bishop of Grenoble) (sixth century), French bishop
• Hesychius of Miletus (sixth century), Greek chronicler and biographer