In enzymology, a calmodulin-lysine N-methyltransferase (EC 2.1.1.60) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + calmodulin L-lysine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + calmodulin N₆-methyl-L-lysine

Thus, the two substrates of this enzyme are S-adenosyl methionine and calmodulin L-lysine, whereas its two products are S-adenosylhomocysteine and calmodulin N6-methyl-L-lysine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase. Other names in common use include S-adenosylmethionine:calmodulin (lysine) N-methyltransferase, and S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase. This enzyme participates in lysine degradation.

References

• Sitaramayya A, Wright LS, Siegel FL (1980). "Enzymatic methylation of calmodulin in rat brain cytosol". J. Biol. Chem. 255 (18): 8894–900. PMID 6773954.